Publications

2021

Landry T, Li P, Shookster D, Jiang Z, Li H, Laing BT, Bunner W, Langton T, Tong Q, Huang H. Centrally circulating α-klotho inversely correlates with human obesity and modulates arcuate cell populations in mice. Mol Metab. 2021 Feb;44:101136. doi: 10.1016/j.molmet.2020.101136. Epub 2020 Dec 7. PMID: 33301986; PMCID: PMC7777546.

Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun Z, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Transl Psychiatry. 2021 Jan 5;11(1):11. doi: 10.1038/s41398-020-01161-1. PMID: 33414382; PMCID: PMC7791100.

2020

Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel BR, Wu Q, Shu G, Tong Q. Profound and redundant functions of arcuate neurons in obesity development. Nat Metab. 2020 Aug;2(8):763-774. doi: 10.1038/s42255-020-0229-2. Epub 2020 Jul 27. PMID: 32719538; PMCID: PMC7687864.

Kim ER, Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Van Drunen R, Ribas-Latre A, Cai ZL, Xue M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q. Paraventricular hypothalamus mediates diurnal rhythm of metabolism. Nat Commun. 2020 Jul 30;11(1):3794. doi: 10.1038/s41467-020-17578-7. PMID: 32732906; PMCID: PMC7393104.

Zhu C, Xu Y, Jiang Z, Tian JB, Cassidy RM, Cai ZL, Shu G, Xu Y, Xue M, Arenkiel BR, Jiang Q, Tong Q. Disrupted hypothalamic CRH neuron responsiveness contributes to diet-induced obesity. EMBO Rep. 2020 Jul 3;21(7):e49210. doi: 10.15252/embr.201949210. Epub 2020 May 27. PMID: 32462726; PMCID: PMC7332802.

He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun. 2020 May 1;11(1):2165. doi: 10.1038/s41467-020-15982-7. PMID: 32358493; PMCID: PMC7195451.

2019

Xu Y, Lu Y, Cassidy RM, Mangieri LR, Zhu C, Huang X, Jiang Z, Justice NJ, Xu Y, Arenkiel BR, Tong Q. Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses. Nat Commun. 2019 Aug 1;10(1):3446. doi: 10.1038/s41467-019-11399-z. PMID: 31371721; PMCID: PMC6671997.

Mangieri LR, Jiang Z, Lu Y, Xu Y, Cassidy RM, Justice N, Xu Y, Arenkiel BR, Tong Q. Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit. eNeuro. 2019 Jul 29;6(4):ENEURO.0156-19.2019. doi: 10.1523/ENEURO.0156-19.2019. PMID: 31331938; PMCID: PMC6664144.

Patel JM, Swanson J, Ung K, Herman A, Hanson E, Ortiz-Guzman J, Selever J, Tong Q, Arenkiel BR. Sensory perception drives food avoidance through excitatory basal forebrain circuits. Elife. 2019 May 10;8:e44548. doi: 10.7554/eLife.44548. PMID: 31074744; PMCID: PMC6510534.

Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A Jr, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O’Rahilly S, Tong Q; UK10K Consortium, Inês Barroso, O’Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 Apr 12;10(1):1718. doi: 10.1038/s41467-019-08737-6. PMID: 30979869; PMCID: PMC6461669.

Gu M, Zhao P, Zhang S, Fan S, Yang L, Tong Q, Ji G, Huang C. Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice. Br J Pharmacol. 2019 Apr;176(7):847-863. doi: 10.1111/bph.14570. Epub 2019 Mar 18. PMID: 30635917; PMCID: PMC6433649.

Cassidy RM, Lu Y, Jere M, Tian JB, Xu Y, Mangieri LR, Felix-Okoroji B, Selever J, Xu Y, Arenkiel BR, Tong Q. A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues. Sci Adv. 2019 Mar 6;5(3):eaav1640. doi: 10.1126/sciadv.aav1640. PMID: 30854429; PMCID: PMC6402846.

Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O’Driscoll M, Morton JEV; DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019 Feb;22(2):205-217. doi: 10.1038/s41593-018-0311-1. Epub 2019 Jan 21. Erratum in: Nat Neurosci. 2019 Sep;22(9):1533. PMID: 30664766; PMCID: PMC6361549.

2018

Wu Q, Han Y, Tong Q. Current Genetic Techniques in Neural Circuit Control of Feeding and Energy Metabolism. Adv Exp Med Biol. 2018;1090:211-233. doi: 10.1007/978-981-13-1286-1_12. PMID: 30390293; PMCID: PMC7673917.

Zhao Y, Li X, Yang L, Eckel-Mahan K, Tong Q, Gu X, Kolonin MG, Sun K. Transient Overexpression of Vascular Endothelial Growth Factor A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System. Mol Cell Biol. 2018 Oct 29;38(22):e00242-18. doi: 10.1128/MCB.00242-18. PMID: 30126894; PMCID: PMC6206456.

Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A Jr, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 Apr 18;9(1):1544. doi: 10.1038/s41467-018-03796-7. PMID: 29670083; PMCID: PMC5906443.

Mangieri LR, Lu Y, Xu Y, Cassidy RM, Xu Y, Arenkiel BR, Tong Q. A neural basis for antagonistic control of feeding and compulsive behaviors. Nat Commun. 2018 Jan 4;9(1):52. doi: 10.1038/s41467-017-02534-9. PMID: 29302029; PMCID: PMC5754347.

Xu J, Zhu C, Zhang M, Tong Q, Wan X, Liao Z, Cai X, Xu Y, Yuan Y, Wang L, Zhu X, Wang S, Gao P, Xi Q, Xu Y, Jiang Q, Shu G. Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway. Metabolism. 2018 Feb;79:10-23. doi: 10.1016/j.metabol.2017.10.006. Epub 2017 Nov 24. PMID: 29080813.

2017 and earlier

Sopariwala DH, Yadav V, Badin PM, Likhite N, Sheth M, Lorca S, Vila IK, Kim ER, Tong Q, Song MS, Rodney GG, Narkar VA. Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting. Sci Rep. 2017 Aug 31;7(1):10237. doi: 10.1038/s41598-017-10238-9. PMID: 28860475; PMCID: PMC5578977.

Kim ER, Fan S, Akhmedov D, Sun K, Lim H, O’Brien W, Xu Y, Mangieri LR, Zhu Y, Lee CC, Chung Y, Xia Y, Xu Y, Li F, Sun K, Berdeaux R, Tong Q. Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply. JCI Insight. 2017 Jul 20;2(14):e93367. doi: 10.1172/jci.insight.93367. PMID: 28724789; PMCID: PMC5518553.

Dai J, Du X, Yin G, Zhang Y, Xia H, Li X, Cassidy R, Tong Q, Chen D, Teixeira AL, Zheng Y, Ning Y, Soares JC, He MX, Zhang XY. Prevalence, demographic and clinical features of comorbid depressive symptoms in drug naïve patients with schizophrenia presenting with first episode psychosis. Schizophr Res. 2018 Mar;193:182-187. doi: 10.1016/j.schres.2017.06.029. Epub 2017 Jun 23. PMID: 28651908.

Gu M, Zhang Y, Liu C, Wang D, Feng L, Fan S, Yang B, Tong Q, Ji G, Huang C. Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases. Br J Pharmacol. 2017 Sep;174(18):3032-3044. doi: 10.1111/bph.13933. Epub 2017 Aug 11. PMID: 28646531; PMCID: PMC5573424.

Cassidy RM, Tong Q. Hunger and Satiety Gauge Reward Sensitivity. Front Endocrinol (Lausanne). 2017 May 18;8:104. doi: 10.3389/fendo.2017.00104. PMID: 28572791; PMCID: PMC5435754.

Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. 2017 May 26;4(3):ENEURO.0083-17.2017. doi: 10.1523/ENEURO.0083-17.2017. PMID: 28560316; PMCID: PMC5446488.

Vojnits K, Pan H, Dai X, Sun H, Tong Q, Darabi R, Huard J, Li Y. Functional Neuronal Differentiation of Injury-Induced Muscle-Derived Stem Cell-Like Cells with Therapeutic Implications. Sci Rep. 2017 Apr 26;7(1):1177. doi: 10.1038/s41598-017-01311-4. PMID: 28446779; PMCID: PMC5430871.

Gu M, Zhang S, Zhao Y, Huang J, Wang Y, Li Y, Fan S, Yang L, Ji G, Tong Q, Huang C. Cycloastragenol improves hepatic steatosis by activating farnesoid X receptor signalling. Pharmacol Res. 2017 Jul;121:22-32. doi: 10.1016/j.phrs.2017.04.021. Epub 2017 Apr 18. PMID: 28428116.

Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Yan X, Hyseni I, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism. 2017 May;70:152-159. doi: 10.1016/j.metabol.2016.12.004. Epub 2016 Dec 13. PMID: 28403939; PMCID: PMC5407306.

Kim ER, Tong Q. Oxygen Consumption Rate and Energy Expenditure in Mice: Indirect Calorimetry. Methods Mol Biol. 2017;1566:135-143. doi: 10.1007/978-1-4939-6820-6_13. PMID: 28244047.

Hinton AO Jr, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016 Dec 22;11(12):e0168644. doi: 10.1371/journal.pone.0168644. PMID: 28006821; PMCID: PMC5179266.

He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A Jr, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016 Nov 8;17(7):1807-1818. doi: 10.1016/j.celrep.2016.10.044. PMID: 27829152; PMCID: PMC6248907.

Gu M, Zhao P, Huang J, Zhao Y, Wang Y, Li Y, Li Y, Fan S, Ma YM, Tong Q, Yang L, Ji G, Huang C. Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X Receptor. Front Pharmacol. 2016 Sep 28;7:345. doi: 10.3389/fphar.2016.00345. PMID: 27733832; PMCID: PMC5039206.

Xu Y, Tong Q. Central leptin action on euglycemia restoration in type 1 diabetes: Restraining responses normally induced by fasting? Int J Biochem Cell Biol. 2017 Jul;88:198-203. doi: 10.1016/j.biocel.2016.09.027. Epub 2016 Oct 1. PMID: 27702650.

Herman AM, Ortiz-Guzman J, Kochukov M, Herman I, Quast KB, Patel JM, Tepe B, Carlson JC, Ung K, Selever J, Tong Q, Arenkiel BR. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. 2016 Oct 13;538(7624):253-256. doi: 10.1038/nature19789. Epub 2016 Oct 3. PMID: 27698417; PMCID: PMC5507212.

Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton A Jr, Zhu L, Shu G, Myers MG Jr, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry. 2017 May 1;81(9):737-747. doi: 10.1016/j.biopsych.2016.06.005. Epub 2016 Jun 9. PMID: 27516377; PMCID: PMC5148733.

Hu Y, Robichaux WG 3rd, Mei FC, Kim ER, Wang H, Tong Q, Jin J, Xu M, Chen J, Cheng X. Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue. Mol Cell Biol. 2016 Sep 12;36(19):2440-50. doi: 10.1128/MCB.01034-15. PMID: 27381457; PMCID: PMC5021373.

Badin PM, Vila IK, Sopariwala DH, Yadav V, Lorca S, Louche K, Kim ER, Tong Q, Song MS, Moro C, Narkar VA. Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice. Sci Rep. 2016 May 25;6:26442. doi: 10.1038/srep26442. PMID: 27220353; PMCID: PMC4879541.

Hinton AO Jr, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen Receptor-α in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females. Hypertension. 2016 Jun;67(6):1321-30. doi: 10.1161/HYPERTENSIONAHA.116.07175. Epub 2016 Apr 18. PMID: 27091896; PMCID: PMC4865414.

Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Sci Rep. 2016 Mar 18;6:23459. doi: 10.1038/srep23459. PMID: 26988598; PMCID: PMC4796901.

Feng L, Luo H, Xu Z, Yang Z, Du G, Zhang Y, Yu L, Hu K, Zhu W, Tong Q, Chen K, Guo F, Huang C, Li Y. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice. Diabetologia. 2016 Jun;59(6):1276-86. doi: 10.1007/s00125-016-3912-9. Epub 2016 Mar 16. PMID: 26983922.

Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton AO Jr, Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line. Metabolism. 2016 Apr;65(4):522-32. doi: 10.1016/j.metabol.2015.12.011. Epub 2015 Dec 29. PMID: 26975544; PMCID: PMC4794642.

Xu Y, Chang JT, Myers MG Jr, Xu Y, Tong Q. Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release. Diabetes. 2016 Apr;65(4):1040-9. doi: 10.2337/db15-1160. Epub 2016 Jan 28. PMID: 26822087; PMCID: PMC4806656.

Fan S, Dakshinamoorthy J, Kim ER, Xu Y, Huang C, Tong Q. An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide Y. Sci Rep. 2016 Jan 27;6:19980. doi: 10.1038/srep19980. PMID: 26813148; PMCID: PMC4728490.

Zhang Y, Gu M, Cai W, Yu L, Feng L, Zhang L, Zang Q, Wang Y, Wang D, Chen H, Tong Q, Ji G, Huang C. Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency. Sci Rep. 2016 Jan 18;6:19288. doi: 10.1038/srep19288. PMID: 26775807; PMCID: PMC4726074.

Zhu L, Xu P, Cao X, Yang Y, Hinton AO Jr, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec;156(12):4474-91. doi: 10.1210/en.2015-1660. Epub 2015 Sep 16. PMID: 26375425; PMCID: PMC4655219.

Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton AO Jr, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates Pro-Opiomelanocortin Neurons in the Arcuate Nucleus. Neuroendocrinology. 2016;103(5):476-488. doi: 10.1159/000439436. Epub 2015 Aug 25. PMID: 26337236; PMCID: PMC4767704.

Kim ER, Wu Z, Sun H, Xu Y, Mangieri LR, Xu Y, Tong Q. Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia. J Neurosci. 2015 Jul 22;35(29):10440-50. doi: 10.1523/JNEUROSCI.1110-15.2015. PMID: 26203139; PMCID: PMC4510285.

Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton AO Jr, Zou F, Ding H, Xia Y, Yan C, Shu G, Wu SP, Yang B, Feng Y, Clegg DJ, DeMarchi R, Khan SA, Tsai SY, DeMayo FJ, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in medial amygdala neurons regulates body weight. J Clin Invest. 2015 Jul 1;125(7):2861-76. doi: 10.1172/JCI80941. Epub 2015 Jun 22. PMID: 26098212; PMCID: PMC4563687.

Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO Jr, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol. 2015 Jul;172(14):3510-21. doi: 10.1111/bph.13141. Epub 2015 May 11. PMID: 25817043; PMCID: PMC4507156.

Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A Jr, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun;156(6):2114-23. doi: 10.1210/en.2014-1922. Epub 2015 Mar 25. PMID: 25807042; PMCID: PMC4430614.

Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci. 2015 Feb 25;35(8):3312-8. doi: 10.1523/JNEUROSCI.3720-14.2015. PMID: 25716832; PMCID: PMC4339348.

Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J. CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. Antioxid Redox Signal. 2015 Apr 1;22(10):819-31. doi: 10.1089/ars.2014.6017. Epub 2015 Feb 18. PMID: 25556857; PMCID: PMC4367236.

Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton A Jr, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest. 2014 Oct;124(10):4351-62. doi: 10.1172/JCI74726. Epub 2014 Aug 26. PMID: 25157819; PMCID: PMC4191033.

Xu Y, Kim ER, Fan S, Xia Y, Xu Y, Huang C, Tong Q. Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochem Biophys Res Commun. 2014 Aug 22;451(2):184-9. doi: 10.1016/j.bbrc.2014.07.079. Epub 2014 Jul 24. PMID: 25065745; PMCID: PMC4162093.

Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y, Tong Q. Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metab. 2013 Dec 3;18(6):860-70. doi: 10.1016/j.cmet.2013.11.003. PMID: 24315371; PMCID: PMC3880549.

Xu Y, Kim ER, Zhao R, Myers MG Jr, Munzberg H, Tong Q. Glutamate release mediates leptin action on energy expenditure. Mol Metab. 2013 Jan 29;2(2):109-15. doi: 10.1016/j.molmet.2013.01.004. PMID: 24199156; PMCID: PMC3817390.

Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 2;18(1):86-98. doi: 10.1016/j.cmet.2013.06.014. PMID: 23823479; PMCID: PMC3752162.

Liu T, Wang Q, Berglund ED, Tong Q. Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit. Front Neurosci. 2013 Jan 21;6:200. doi: 10.3389/fnins.2012.00200. PMID: 23346045; PMCID: PMC3549528.

Tong Q, Xu Y. Central Leptin Regulation of Obesity and Fertility. Curr Obes Rep. 2012 Dec 1;1(4):236-244. doi: 10.1007/s13679-012-0025-8. PMID: 23243628; PMCID: PMC3519445.

Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012 Oct 26;151(3):645-57. doi: 10.1016/j.cell.2012.09.020. PMID: 23101631; PMCID: PMC3500616.

Wu Z, Xu Y, Zhu Y, Sutton AK, Zhao R, Lowell BB, Olson DP, Tong Q. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One. 2012;7(9):e45167. doi: 10.1371/journal.pone.0045167. Epub 2012 Sep 18. PMID: 23028821; PMCID: PMC3445456.

Xu Y, O’Brien WG 3rd, Lee CC, Myers MG Jr, Tong Q. Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology. 2012 May;153(5):2223-33. doi: 10.1210/en.2011-2071. Epub 2012 Feb 14. PMID: 22334723; PMCID: PMC3339652.

Xu Y, Tong Q. Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation. Protein Cell. 2011 Oct;2(10):800-13. doi: 10.1007/s13238-011-1112-4. Epub 2011 Nov 6. PMID: 22058035; PMCID: PMC4875302.

Tong Q. Synaptotagmin 4: a new antiobesity target? Neuron. 2011 Feb 10;69(3):401-3. doi: 10.1016/j.neuron.2011.01.018. PMID: 21315251; PMCID: PMC3061285.

Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron. 2010 Nov 4;68(3):543-56. doi: 10.1016/j.neuron.2010.09.008. PMID: 21040853; PMCID: PMC2991105.

Kong D, Vong L, Parton LE, Ye C, Tong Q, Hu X, Choi B, Brüning JC, Lowell BB. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010 Nov 3;12(5):545-52. doi: 10.1016/j.cmet.2010.09.013. PMID: 21035764; PMCID: PMC2998191.

Song J, Xu Y, Hu X, Choi B, Tong Q. Brain expression of Cre recombinase driven by pancreas-specific promoters. Genesis. 2010 Nov;48(11):628-34. doi: 10.1002/dvg.20672. Epub 2010 Oct 19. PMID: 20824628; PMCID: PMC3641578.

Zhou L, Podolsky N, Sang Z, Ding Y, Fan X, Tong Q, Levin BE, McCrimmon RJ. The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia. Diabetes. 2010 Oct;59(10):2646-52. doi: 10.2337/db09-0995. Epub 2010 Jul 13. PMID: 20627933; PMCID: PMC3279559.

Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci. 2009 Jul 22;29(29):9361-9. doi: 10.1523/JNEUROSCI.0737-09.2009. PMID: 19625526; PMCID: PMC2758912.

Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Sep;11(9):998-1000. doi: 10.1038/nn.2167. PMID: 19160495; PMCID: PMC2662585.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 2007 May;5(5):383-93. doi: 10.1016/j.cmet.2007.04.001. PMID: 17488640; PMCID: PMC1934926.

Tong Q, Kirchgessner AL. Localization and function of metabotropic glutamate receptor 8 in the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G992-G1003. doi: 10.1152/ajpgi.00118.2003. Epub 2003 Jun 26. PMID: 12829438.

Tong Q, Ouedraogo R, Kirchgessner AL. Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets. Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1324-33. doi: 10.1152/ajpendo.00460.2001. PMID: 12006363.